Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The five fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG), nuclear medicine (NucMed) and advanced x-ray tomographic imaging (AXTI). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.

Highlight

Grob et al. have published a paper in European Radiology entitled: Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice


Subtraction computed tomography (SCT) is a technique that uses software-based motion correction between an unenhanced and an enhanced CT scan for obtaining the iodine distribution in the pulmonary parenchyma. This technique has been implemented in clinical practice for the evaluation of lung perfusion in CT pulmonary angiography (CTPA) in patients with suspicion of acute and chronic pulmonary embolism, with acceptable radiation dose. This paper discusses the technical principles, clinical interpretation, benefits and limitations of arterial subtraction CTPA.


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Key Points: • SCT uses motion correction and image subtraction between an unenhanced and an enhanced CT scan to obtain iodine distribution in the pulmonary parenchyma. • SCT could have an added value in detection of pulmonary embolism. • SCT requires only software implementation, making it potentially more widely available for patient care than dual-energy CT.


See more in the Highlight Archive.

News

  • August 20, 2019: Anne Saris will defend her PhD thesis with the title 'Blood velocity vector imaging in the carotid artery using ultrasound' at 14.30.
  • July 2, 2019: Stein Fekkes will defend his PhD thesis with the title '3D Carotid Elastography'at 14.30.
  • April 19, 2019: Tom H. Peeters et.al. have published a paper in ACS Chemical Neuroscience entitled: Imaging Hyperpolarized Pyruvate and Lactate after Blood−Brain Barrier Disruption with Focused Ultrasound

    ABSTRACT: Imaging of hyperpolarized 13C-labeled substrates has emerged as an important magnetic resonance (MR) technique to study metabolic pathways in real time in vivo. Even though this technique has found its way to clinical trials, in vivo dynamic nuclear polarization is still mostly applied in preclinical models. Its tremendous increase in signal-to-noise ratio (SNR) overcomes the intrinsically low MR sensitivity of the 13C nucleus and allows real-time metabolic imaging in small structures like the mouse brain. However, applications in brain research are limited as delivery of hyperpolarized compounds is restrained by the blood-brain barrier (BBB). A local noninvasive disruption of the BBB could facilitate delivery of hyperpolarized substrates and create opportunities to study metabolic pathways in the brain that are generally not within reach. In this work, we designed a setup to apply BBB disruption in the mouse brain by MR-guided focused ultrasound (FUS) prior to MR imaging of 13C enriched hyperpolarized [1-13C]-pyruvate and its conversion to [1-13C]-lactate. To overcome partial volume issues, we optimized a fast multigradient-echo imaging method (temporal resolution of 2.4 s) with an in-plane spatial resolution of 1.6 × 1.6 mm2, without the need of processing large amounts of spectroscopic data. We demonstrated the feasibility to apply 13C imaging in less than 1 h after FUS treatment and showed a locally disrupted BBB during the time window of the whole experiment. From detected hyperpolarized pyruvate and lactate signals in both FUS-treated and untreated mice, we conclude that even at high spatial resolution, signals from the blood compartment dominate in the 13C images, leaving the interpretation of hyperpolarized signals in the mouse brain challenging

    KEYWORDS: Dynamic nuclear polarization, MRI, focused ultrasound, blood-brain barrier, 13C imaging, 7 T, mouse brain
  • March 28, 2019: Leticia Gallardo Estrella has succesfully defended her PhD thesis, titled ''Quantification of COPD biomarkers in thoracic CT scans".
  • March 26, 2019: Alejandro Rodriguez-Ruiz has succesfully defended his PhD thesis titled "Artificial intelligence & tomosynthesis for breast cancer detection".
  • March 18, 2019: Domenico Pangallo joined the AXTI group for his MSc thesis about quantitative image analysis of breast cancer in dedicated breast CT imaging, under the supervision of Marco Caballo.
  • March 10, 2019: Twan Cuijpers joined the AXTI group for his MSc internship. He will work with Joana Boita in a project from LRCB (Dutch Expert Centre for Screening) that intends to create a visualization tool for teaching in mammography.
  • February 26, 2019: Rick Philipsen has succesfully defended his PhD thesis, titled 'Automated chest radiography reading: improvements, validation, and cost-effectiveness analysis'.
  • January 30, 2019: Thomas van den Heuvel defended his thesis on Automated low-cost ultrasound. He showed that a deep learning system can perform real-time detection of risk factors for pregnant women using the input from a low-cost ultrasound device. His work was covered by NOS op 3, national radio, Algemeen Dagblad, Medisch Contact, and RTL Z. Next month, Thomas will return to Ethiopia for further testing of his device.
  • January 24, 2019: Ioannis Sechopoulos was named Fellow of the American Association of Physicists in Medicine ( AAPM) due to his distinguished contributions to medical physics and the esteem in which he is held by his peers
  • January 18, 2019: Roel Verhoeven won the 'Best clinical poster award' at the Imaging the Biomechanics of Life (TOPIM) conference in Les Houches, France as hosted by the European Society for Molecular Imaging. Apart from a great sweater as a rememberance to this award, he more importantly got the opportunity to again present his work as an oral presentation for the main audience!
  • December 20, 2018: Kaj Gijsbertse has succesfully defended his PhD thesis entitled: Functional ultrasound imaging of the lower extremity
  • December 11, 2018: Wulphert Venderink has obtained his PhD.
  • December 11, 2018: Jan Jurre Mordang has succesfully defended his PhD thesis with the title ' Towards an independent observer of screening mammograms: detection of calcifications'.
  • December 7, 2018: Marlene Hekman has obtained her PhD.
  • December 5, 2018: The work by Marco Caballo and Ioannis Sechopoulos about using machine learning to generate super-resolution digital breast phantoms for accurate simulations of new imaging systems, published in Physics in Medicine and Biology, was covered in Physics World and in Aunt Minnie
  • November 27, 2018: Francesco Ciompi and Jeroen van der Laak have been awarded an ICT12 Horizon 2020 grant as part of a consortium of European partners. The goal of this 4-year project, EXA MODE, is to build tools based on artificial intelligence to aid pathologists in routine diagnostics via automatic analysis of digital pathology whole-slide images of cancer specimens across multiple organs.
  • November 23, 2018: Dagmar Grob was awarded for the best 4-slide short talk at the PhD retreat of Radboud Institute for Health Sciences (22 - 23 November 2018)
  • November 8, 2018: The consortium led by Chris de Korte was awarded an NWO Perspectief grant for ultra-X-treme: ultrafast ultrasound imaging for extended diagnosis and treatment of vascular disease. Five academic partners (Radboudumc, ErasmusMC, University of Twente, University of Technology Delft, and Eindhoven University of Technology) together with 8 industrial partners (Philips, Tomtec, Vermon, Mindray, Bracco, Ansys, Pie Medical Imaging and Verasonics) and two hospitals (Catherina ziekenhuis Eindhoven, Rijnstate) will join forces to make vascular interventions really patient specific.
  • November 5, 2018: Marta Pinto started working as a PhD student at the AXTI group, focusing on image processing algorithms for image quality improvement in digital breast tomosynthesis.

For older news, see the News Archive.